Scientific Programme
Scientific
Programme
| 02 NOVEMBER 2022 – WEDNESDAY | |
| 12.00 | Registration |
| HALL – A (This session will be in Turkish) | |
| 13.30-16.00 | Biyoteknolojik İlaçlarda Klinik Çalışmalar-Güvenlik Değerlendirmeleri Safety Evaluations and Clinical Studies in Biotechnological Products Chairs: Semra Şardaş, Gül Özhan |
| 13.30-14.00 | Biyoteknolojik İlaçlar ve Üretim Süreçleri Devrim Demir Dora |
| 14.00-14.30 | Biyobenzer İlaçlarda Klinik Çalışmalar ve Karşılaştırılabilirlik İrfan Çiçin (Online) |
| 14.30-15.00 | Biyobenzer Ürünlerde Ekstrapolasyon, Değiştirilebilirlik M.Cem Ar (Online) |
| 15.00-15.30 | Biyoüstünler Alper B. İskit |
| 15.30-16.00 | Biyolojik ve Biyobenzer İlaçlarda Farmakovijilans, İzlenebilirlik ve Risk Yönetimi Semra Şardaş |
| 17.00-18.30 | Opening Ceremony |
| 17.30-18.15 | Opening Lecture Chair: Nurşen Başaran The History of the Advancement of Toxicology in Turkey Ali Esat Karakaya |
| 18.00-20.00 | Opening Reception |
| 20.00 | Dinner |
| 03 NOVEMBER 2022 – THURSDAY | |
| HALL – A | |
| 09.00-9.45 | Plenary Lecture Chair: Ali Esat Karakaya Non-Pharmacological Mechanism in Substance-Based Medical Devices/Challenges in Regulatory Definition Marco Racchi |
| 09.45-10.00 | Coffee Break |
| HALL – A, SESSION 1 | |
| 10.00-12.00 | Genotoxic Impurities in Pharmaceutical Compounds Chairs: Lutz Mueller, Ahmet Aydın |
| 10.00-10.30 | The staged TTC concept in the evaluation og genotoxic impurities in drugs Lutz Mueller |
| 10.30-11.00 | Strategies on the assessment of genotoxic impurities in pharmaceuticals Andreas Czich (online) |
| 11.00-11.30 | Regulation of Genotoxic Impurities – Guidelines and Experiences since 2006 Roland Froetschl |
| 11.30-12.00 | Genotoxic impurities and other possible impurities in pharmaceutical products: From the application perspective Ahmet Aydın |
| 12.00-13.30 | Lunch |
| HALL – A | |
| 13.30-14.15 | Plenary Lecture Chair: José E. Manautou Chemical Stewardship through Sustainability Lenses Salmaan H Inayat-Hussain |
| HALL – A, SESSION 2 | |
| 14.30-17.00 | Vaccine Safety-Toxicity and Clinical Trials Chairs: Asuman Karakaya, Pınar Erkekoğlu |
| 14.30-15.00 | Vaccine Safety and Toxicity. What have We Learned from COVID-19 Pandemic Pınar Erkekoğlu |
| 15.00-15.30 | Clinical Trials of COVID-19 Vaccines Serhat Ünal |
| 15.30-16.00 | Vaccine Hesitancy Levent Akın |
| 16.00-16.30 | Pharmacoeconomic Aspects of COVID-19 Vaccines Zafer Çalışkan |
| 16.30-17.00 | Characterization and Quality Control Procedures for Vaccines: A Special Focus on COVID-19 Vaccines Emirhan Nemutlu |
| 17.00-17.15 | Coffee Break |
| HALL – B, SESSION 3 | |
| 14.30-17.00 | Current approaches on detecting the DNA damage and repair of chemicals Chairs: Bensu Karahalil, Neslihan Aygün Kocabaş |
| 14.30-15.00 | Genetic risks from heat-damaged DNA in food Miral Dizdaroğlu (online) |
| 15.00-15.30 | Mode of action (MOA) based threshold for genotoxic carcinogens: Benzene case Neslihan Aygün Kocabaş |
| 15.30-16.00 | Mitochondrial DNA damage as genotoxicity marker Nadja Cristhina de Souza Pinto (online) |
| 16.00-16.30 | The impacts of prominent detoxifying and repair gene polymorphisms on neurological diseases Bensu Karahalil |
| 16.30-17.00 | In vitro genotoxicity of two graphene oxides before and after prolonged mild thermal treatment Sanin Haveric |
| 17.00-17.15 | Coffee Break |
| HALL – A, SESSION 4 | |
| 17.15-19.15 | Scientific Approach to Chemical Warfare and Fourth Generation Nerve Agents_Novichoks Chairs: Onur Erdem, Sermet Sezigen |
| 17.15-17.45 | A generic presentation on fourth generation agents and their risks – novel therapeutic options for nerve agents/organophosphates poisoning Ahmet Aydın |
| 17.45-18.15 | Case studies for Novichok incidents in UK and Russia Sermet Sezigen |
| 18.15-18.45 | Review-based evaluation of decontamination techniques after Novichok exposure Denis Josse (online) |
| 18.45-19.15 | In-vitro and Pre-Clinical Studies of Decontamination Efficacy of Chemical Warfare agents from the skin Laura Cochrane (online) |
| 20.00 | Dinner |
| HALL – B, SESSION 5 | |
| 17.15-19.15 | Environmental Biomonitoring of Hazardous Substances Chairs: Anja Haveric, Yalçın Duydu |
| 17.15-17.45 | Air pollution context and biomonitoring in Sarajevo, Bosnia and Herzegovina Anja Haveric |
| 17.45-18.15 | Does research in the field of Occupational Toxicology of Metals have any Future in Developed Countries? Petar Bulat |
| 18.15-18.45 | Tobacco during pregnancy: looking at self-reported tobacco exposure, urinary cotinine levels and perinatal outcomes Carla Costa |
| 18.45-19.15 | Monitoring air pollution and the health-related biomarkers: lessons from HUMNap Katarina Matkovic |
| 20.00 | Dinner |
| HALL – C | |
| 14.30-16.30 | Industry Sponsored Workshop / MAT-TEK The workshop will provide a brief overview of in vitro 3D reconstructed human tissue models and their use in toxicology and pharmacology as well as the practical demonstration of EpiDerm Skin Irritation Test (SIT) according to OECD test guideline 439 (TG 439). EpiDerm 3D human tissue model is used across a diverse range of applications including safety and risk assessment, and biological efficacy. Simple protocols and the evaluation of early cellular endpoints allow researchers to acquire data in few days. EpiDerm, a Reconstructed Human Epidermis (RHE), is ready-to-use, highly differentiated 3D tissue model consisting of normal, human-derived epidermal keratinocytes (NHEK) cultured on specially prepared tissue culture inserts cultured at the air-liquid interface (ALI) and allows for the evaluation of topically applied compounds, chemicals, cosmetic/personal care product ingredients and final formulations. With multiple ECVAM validations and OECD accepted test guidelines, EpiDerm is a proven in vitro model system for chemical, pharmaceutical and skin care product testing. EpiDerm SIT is validated and accepted method under OECD TG 439, EpiDerm Skin Corrosion test as OECD TG 431 and EpiDerm phototoxicity test as OECD TG 498. Participants will have a hands-on opportunity to practice the EpiDerm SIT with actual tissue models. The workshop is suitable for everybody who would like to practice the method, consult the specific problem, get information as well as those who are just considering the use of in vitro models in their research. Please, sign in at MatTek´ s booth. Number of participants for practical work is limited to 30. |
| 16.30-16.45 | Coffee Break |
| 16.45-18.50 | Industry Sponsored Presentation & Oral Presentations 1 Chairs: Ülkü Ündeğer Bucurgat, Bülent Ergun |
| 16.45-17.00 | Industry Sponsored Presentation / Redoks Orbitrap (HR)-MS Applications in Toxicological Drug Screening |
| 17.00-17.10 | Comparison of EU and TR safety guidelines on the use of nanomaterials in cosmetics Yağmur Emre Arıcan |
| 17.10-17.20 | In silico prediction of ADME and toxicity profiles of the drug candidates Tuğçe Yeşil |
| 17.20-17.30 | Evaluation of neopterin levels and kynurenine pathway in acute coronary syndrome patients Sonia Sanajou |
| 17.30-17.40 | Modifying Effects of Gender on the Toxicity of Methyl Mercury and Thimerosal Selinay Başak Erdemli-Köse |
| 17.40-17.50 | Evaluation of Possible Toxic Effects of Preservatives and Adjuvants Used in Vaccines Anıl Yirun |
| 17.50-18.00 | Comparison of possible cytotoxic effects in healthy and cancer cells and evaluation of antioxidant capacities of polymeric nanoparticles encapsulated with naringin and berberine Jülide Secerli |
| 18.00-18.10 | Hepatotoxicity induced by low doses of Pb: subacute toxicity study in rats and Benchmark modeling Dragana Javorac |
| 18.10-18.20 | The protective role of UMCA on bleomycin-induced lung fibrosis in rats Sezgin Aydemir |
| 18.20-18.30 | Are rare earth elements safe for use in zootechny?; trophic transfer and effects of lanthanide nanoparticles in a simple food web Daniel Mark Lyons |
| 18.30-18.40 | Microplastics: How aware are we? Özge Sultan Zengin |
| 18.40-18.50 18.50-19.00 | Medroxyprogesterone Acetate And Ethodolac Exposure Durıng Pregnancy Elif Onat Cerebral oxidative stress and histological changes induced by di (2-ethyl hexyl) phthalate exposure in early adolescent and adolescent periods in rats Deniz Özkan Vardar |
| 04 NOVEMBER 2022 – FRIDAY | |
| HALL – A | |
| 09.00-09.45 | Plenary Lecture Chair: Gülden Omurtag Safety Evaluation of Food Additives Yalçın Duydu |
| 09.45-10.00 | Coffee Break |
| HALL – A, SESSION 6 | |
| 10.00-12.30 | Application of Comet Assay in Human Biomonitoring Chairs: Mirta Milic, Joao Paolo Texeira |
| 10.00-10.30 | The comet assay in human biomonitoring: results from the COST Action hCOMET Andrew Collins |
| 10.30-11.00 | Suitability of salivary leucocytes to assess DNA damage and repair in human biomonitoring studies using the comet assay Blanca Laffon |
| 11.00-11.30 | Characterization of Portuguese Wildland firefighters before a Wildfire Season: Looking at the cytogenetic effects Joao Paolo Texeira |
| 11.30-12.00 | Effect of a meat-based diet on fecal water genotoxicity: a randomized clinical trial in healthy subjects Lisa Giovannelli |
| 12.00-12.30 | The damage and protective effects on DNA after single use combination of volatile anaesthetics and gamma radiation radiotherapy of 1 or 2Gy in vivo: preliminary results Mirta Milic |
| 12.30-13.45 | Lunch |
| HALL – A, SESSION 7 | |
| 13.45-15.45 | In Silico Toxicology Chairs: Hande Sipahi, Kristie Sullivan |
| 13.45-14.15 | Regulatory Applications of Computational Toxicology: Progress and Strategies to Ensure Wider Use Kristie Sullivan |
| 14.15-14.45 | In silico approaches to assess the potential environmental effects of diverse chemicals Melek Türker Saçan |
| 14.45-15.15 | Filling data gap for toxicological evaluation of pharmaceuticals: In Silico approach Muhammed Hamitoğlu |
| 15.15-15.45 | In silico toxicological evaluation of drug impurities aligned with ICH M7. A case study for methylprednisolone aceponate impurities Gülçin Tuğcu |
| 15.45-16.00 | Coffee Break |
| HALL – B, SESSION 8 | |
| 13.45-15.45 | Current Concerns about Endocrine Disrupting Chemicals Chairs: Hande Gürer Orhan, Belma Koçel Gümüşel |
| 13.45-14.15 | Causality Between Prenatal Exposure to Pharmaceuticals and Childhood Obesity Hande Gürer Orhan |
| 14.15-14.45 | Epigenetic Effects of Endocrine Disrupting Chemicals Belma Koçer Gümüşel |
| 14.45-15.15 | Zebrafish as a Model for Chemical Induced Adipogenesis and Related Metabolic Diseases Jorke Kamstra |
| 15.15-15.45 | Risk Assessment of Endocrine Disruptors Johanna Zilliacus |
| 15.45-16.00 | Coffee Break |
| HALL – A, SESSION 9 | |
| 16.00-18.00 | Organ-specific Toxic Pathways: recent progress in drug-induced adversities Chairs: Hilmi Orhan, Mathieu Vinken |
| 16.00-16.30 | Paracetamol-induced kidney damage occurs by different mechanism from hepatotoxicity Hilmi Orhan |
| 16.30-17.00 | Adverse outcome pathways for in vitro prediction of liver toxicity Mathieu Vinken |
| 17.00-17.30 | The role of mitochondria in cell death and regeneration during acetaminophen hepatotoxicity Anup Ramachandran |
| 17.30-18.00 | Increasing complexity of in vitro models for drug-induced nephrotoxicity enhances their predictive value Silvia Mihaila |
| 20:00 | Gala Dinner |
| HALL – B, SESSION 10 | |
| 16.00-18.00 | Conceptual models in immunotoxicology: alternative approaches and computational strategies Chairs: Özlem Atlı Eklioğlu, Marco Racchi |
| 16.00-16.30 | Key characteristics of immunotoxicants: the way forward? Dori E. Germolec |
| 16.30-17.00 | In vitro tests addressing immunotoxicity with a focus on immunosuppression Emanuela Corsini |
| 17.00-17.30 | Integrated testing strategy for immunotoxicity: the agrochemical example Marco Corvaro |
| 17.30-18.00 | The Universal Immune System Simulator: an in silico model to predict the risk associated with exposure to immunotoxicants Francesco Pappalardo (Online) |
| 20:00 | Gala Dinner |
| HALL – C, | |
| 13.45-15.55 | Oral Presentations 2 Chairs: Sinem Ilgın, Sibel Özden |
| 13.45-13.55 | Role of AhR/CYP1A1 signaling in the interaction between benzo[a]pyrene and chlorpyrifos Burcu Ünlü Endirlik |
| 13:55-14:05 | Determination of exposure to organophosphate flame retardants in preschool children: a human biomonitoring study in three Turkish provinces Hadi Attaran |
| 14:05-14:15 | Cell response to N-alkyl quaternary quinuclidine oxime treatment Suzana Žunec |
| 14:15-14:25 | Biomonitoring of Glyphosate-Based Herbicide Among Farmers in Northern Cyprus: A Pilot Study Kumsal Kocadal |
| 14:25-14:35 | The nematode Caenorhabditis elegans in Toxicity Testing: A pioneering study on the utility of this model organism Fehmi Burak Alkas |
| 14:35-14:45 | Investigation of the presence of volatile organic pollutants (VOCs) in tap water in Ankara provincial districts Onur Kenan Ulutaş |
| 14:45-15:05 | Redox status changes in rat plasma induced by phthalate and bisphenol A mixture after subacute exposure Katarina Baralić |
| 15:05-15:15 | Determination of aflatoxin m1 levels in milk samples consumed in the Turkish Republic of Northern Cyprus Cengiz Bereket |
| 15:15-15:25 | Evaluation of the apoptotic and antioxidant effects of pitavastatin in cervical cancer cell line Aysun Ökçesiz |
| 15:25-15:35 | Assessment of organophosphate and pyrethroid pesticides exposure in preschool children in Türkiye Ayca Aktas Sukuroglu |
| 15:35-15:45 | Antioxidant and protective effects of Artemisia campestris essential oil against chlorpyrifos-induced kidney and liver injuries in rats Mongi Saoudi |
| 15:45-15:55 | Microplastic Pollution in Plant Ecosystems Hakan Özden |
| 15:55-16:10 | Coffee Break |
| 16.10-18.30 | Oral Presentations 3 Chairs: Emre Durmaz, Sevtap Aydın |
| 16:10-16:20 | Effects of COVID-19 disease on DNA damage, oxidative stress and immune responses Merve Hazar |
| 16:20-16:30 | Apoptotic, genotoxic and immunotoxic evaluation of bisphenol derivatives exposure in HepG2 cells Aylin Balcı Ozyurt |
| 16:30-16:40 | Determination of in vitro genotoxic effects of pine resin and Aronia melonacarpa on prostate and breast cancer cell lines by using comet assay technique Ayfer Beceren |
| 16:40-16:50 | Investigation of the cytotoxic and genotoxic effects of royal jelly on healthy and cancer lung cell lines Gökçe Taner |
| 16:50-17:00 | Investigation of the Effects of Zearalenone in the Genes Related to Energy Metabolism In Vitro: Relation with the Epigenetic Alterations. Ecem Fatma Karaman |
| 17:00-17:10 | Promising novel bioinspired materials for theragnostic applications: Is the synthesis of non-cytotoxic and non-genotoxic dipeptide structures possible? Merve Bacanlı |
| 17:10-17:20 | The impact of DNA methylation on the expression of CYP3A4 gene Seher Karslı |
| 17:20-17:30 | Investigation of the Protective Effect of Walnut Oil in an in vitro Alzheimer’s Disease Model Göksun Demirel |
| 17:30-17:40 | Effect of melphalan and epigallocatechin gallate combinations on cytotoxicity in neuroblastoma cell line Cagatay Oltulu |
| 17:40-17:50 | Investigation of the apoptotic properties of combined use of lonidamine and doxorubicin on ln229 human glioblastoma cell line Ayşenur Bilgehan |
| 17:50-18:00 | Cytotoxic effect of abemaciclib in HepG2/THP-1 co-culture model Tugce Boran |
| 18:00-18:10 | In vitro evaluation of copper ferro (II) oxide nanoparticles induced neurotoxicity Mahmoud Abudayyak |
| 18:10-18:20 | Comparative toxicity responses of THS derived from conventional cigarette and heated-tobacco products in human bronchial epithelial cells Rengin Reis |
| 18:20-18:30 | Human induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) model as an assessment tool for cardiotoxicity Zehra Şeker |
| 20:00 | Gala Dinner |
| 05 NOVEMBER 2022 – SATURDAY | |
| HALL – A | |
| 09.00-09.45 | Plenary Lecture Chair: Emanuela Corsini Mutidrug Resistance Protein-4 (Mrp4): A New Member in the Constellation of Factors Contributing to Non-alcoholic Liver Disease and Metabolic Syndrome José E. Manautou |
| 09.45-10.00 | Coffee Break |
| HALL – A, SESSION 11 | |
| 10.00-12.00 | The safety of Nanomaterials Chairs: Heidi Foth, Murat Özmen |
| 10.15-10.45 | Possible interactions and risks between nanoparticles and chemical pollutants in aquatic environments Murat Özmen |
| 10.45-11.15 | Effect of BaSO4 nanoparticles on human lung cells under different culture conditions Heidi Foth |
| 11.15-11.45 | Genotoxicity of engineered nanomaterials: New approaches to hazard and risk assessment Maria Dusinska |
| 12.00 | Closing Remarks |
| HALL – B, SESSION 12 | |
| 10.00-12.00 | Lipids in health and diseases Chairs: Suna Sabuncuoğlu, Petar Bulat |
| 10.15-10.45 | Sterol markers of cholesterol and bile acid metabolism Dieter Luetjohann |
| 10.45-11.15 | Sphingolipid metabolism in toxicological exposures Suna Sabuncuoglu |
| 11.15-11.45 | Role of Ceramides in Insulin Resistance and Diabetic Dyslipidemia From a Biochemical Point of View Mutay Aslan |
| 12.00 | Closing Remarks (Hall A) |
